Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9194564 | Journal of Neuroimmunology | 2005 | 10 Pages |
Abstract
Biochemical, immunohistochemical and functional studies revealed respectively an increase of neutrophils infiltration, of IL-1β, TNF-α immunoreactivity, apoptosis (measured by Annexin-V staining) and loss of hind legs movement in SCI operated 5-LO wild-type mice. In contrast, the degree of (1) neutrophil infiltration at different time points, (2) cytokine expression (TNF-α and IL-1β), (3) histological damage, (4) apoptosis, was markedly reduced in the tissues obtained from SCI operated 5-LO deficient mice and (5) the motor recovery was ameliorated.
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Authors
Tiziana Genovese, Emanuela Mazzon, Antonietta Rossi, Rosanna Di Paola, Giuseppe Cannavò, Carmelo Muià , Concetta Crisafulli, Placido Bramanti, Lidia Sautebin, Salvatore Cuzzocrea,