Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9194659 | Journal of Neuroimmunology | 2005 | 7 Pages |
Abstract
We investigated autoantibodies and their epitope(s) in Hashimoto's encephalopathy associated with Hashimoto's thyroiditis. In a proteomic analysis, they proved to recognize α-enolase. We further searched the epitope region in α-enolase using different regions of recombinant proteins expressed in cultured human cells. The amino terminal region was recognized by autobodies from a much higher proportion of patients with Hashimoto's encephalopathy (83.3%; 5/6) than from patients with Hashimoto's thyroiditis (11.8%; 2/17), and not at all by sera from controls (25 healthy individuals and 25 controls with other neurological disorders) (0%; 0/50). Neither the carboxyl terminal nor the mid-region of α-enolase showed specificity for Hashimoto's encephalopathy. Autoantibodies against the amino terminal of α-enolase are a useful diagnostic marker for Hashimoto's encephalopathy.
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Authors
A. Fujii, M. Yoneda, T. Ito, O. Yamamura, S. Satomi, H. Higa, A. Kimura, M. Suzuki, M. Yamashita, T. Yuasa, H. Suzuki, M. Kuriyama,