| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9194675 | Journal of Neuroimmunology | 2005 | 9 Pages |
Abstract
In the present study, we demonstrated a significant reduction of B lymphocytes in the blood, spleen and bone marrow of BDNF deficient mice. The observed developmental block in bone marrow B cell development was linked specifically to the Pre-BII stage. B lymphocytes express the BDNF receptors p75NTR and TrkBgp95, while no BDNF expression was found. However, a strong BDNF expression was demonstrated in bone marrow stromal cells. An increase of intracellular free calcium [Ca2+]i in B lymphocytes after BDNF application confirms a direct responsiveness of B lymphocytes to BDNF. In conclusion, these results suggest a role of BDNF for normal B lymphocyte development through paracrine effects in the bone marrow.
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Authors
Berit Schuhmann, Alexander Dietrich, Serdar Sel, Christian Hahn, Martin Klingenspor, Marek Lommatzsch, Thomas Gudermann, Armin Braun, Harald Renz, Wolfgang Andreas Nockher,