Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9194708 | Journal of Neuroimmunology | 2005 | 12 Pages |
Abstract
Neuropathogenic murine antibodies reactive with terminal disialylgalactose epitopes are innate and preferentially encoded by the VH7183.3b gene. Here we have studied antibodies reactive with internal galactose-linked disialosyl epitopes and the terminal trisaccharide of GT1b. Antibodies were of moderate affinity and unmutated. Anti-GD1b antibodies were often encoded by the VH10.2b heavy and gj38c light chain genes. Anti-GT1b antibodies with broader glycan binding patterns were encoded by VHQ52 and VHJ558 family genes. These data indicate that the discrete specificities of ganglioside-binding antibodies are dictated by particular patterns of V gene usage residing within the innate B cell repertoire.
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Authors
Judith Boffey, Masaaki Odaka, Dawn Nicoll, Eric R. Wagner, Kate Townson, Tyrone Bowes, Joe Conner, Koichi Furukawa, Hugh J. Willison,