Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9194719 | Journal of Neuroimmunology | 2005 | 6 Pages |
Abstract
Clinical studies have shown that groups of multiple sclerosis (MS) patients exhibit a chronically activated hypothalamo-pituitary-adrenal (HPA) axis. However, the association of HPA axis activity and disease progression in MS is unknown. In this longitudinal study over a 3-year follow-up period, we report that patients who exhibited stronger HPA reactivity at baseline were significantly more likely to experience progression as measured by the Expanded Disability Status Scale (EDSS) during the follow-up period. Furthermore, HPA axis activity correlated with progression ratings and cognitive impairment three years later. Tests of HPA axis activity may be useful biomarkers for disease progression in MS.
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Authors
Stefan M. Gold, Alaleh Raji, Inge Huitinga, Klaus Wiedemann, Karl-Heinz Schulz, Christoph Heesen,