Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9194774 | Journal of Neuroimmunology | 2005 | 10 Pages |
Abstract
Sporadic amyotrophic lateral sclerosis (sALS) is a progressive neuroinflammatory disease of spinal cord motor neurons of unclear etiology. Blood from 38 patients with sALS, 28 aged-match controls, and 25 Alzheimer's disease (AD) patients were evaluated and activated monocyte/macrophages were observed in all patients with sALS and AD; the degree of activation was directly related to the rate of sALS disease progression. Other parameters of T-cell activation and immune globulin levels showed similar disease associated changes. These data are consistent with a disease model previously suggested for AD, wherein systemic immunologic activation plays an active role in sALS.
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Authors
Rongzhen Zhang, Ron Gascon, Robert G. Miller, Deborah F. Gelinas, Jason Mass, Ken Hadlock, Xia Jin, Jeremy Reis, Amy Narvaez, Michael S. McGrath,