Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9194821 | Journal of Neuroimmunology | 2005 | 8 Pages |
Abstract
The acute-phase febrile responses of the inbred Lewis (LEW) and Fischer 344 (F344) rat strains and their parent Sprague-Dawley (S-D) strain to immune challenge with lipopolysaccharide (LPS) were compared. LEW and S-D males and females displayed a biphasic febrile response with a markedly attenuated second phase in F344 rats. At 2 h after LPS (50 μg/kg), corticosterone was significantly higher in F344 than in LEW rats, but serum interleukin-1β was higher only in F344 than LEW males. These data suggest that the greater LPS-induced corticosterone response of F344 rats mediates differences between febrile responses of F344 and LEW males and females.
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Authors
Anna N. Taylor, Delia L. Tio, Horacio E. Romeo,