Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9194839 | Journal of Neuroimmunology | 2005 | 5 Pages |
Abstract
We analyzed the concentrations of four chemokines in the cerebrospinal fluid (CSF) and sera in Vogt-Koyanagi-Harada disease (VKH), an autoimmune uveomeningitis syndrome against melanocyte-associated proteins, with ELISA. CSF-CXCL10/IP-10 and CSF-CCL17/TARC were significantly elevated in VKH than in controls. In the majority of VKH cases and controls, CSF-CXCL10 was higher than serum-CXCL10, and CSF-CCL17 was lower than serum-CCL17. CCL11/Eotaxin was not different between groups. CSF-CCL2/MCP-1 was significantly lower in VKH than in control. The changes in VKH were essentially similar to those in multiple sclerosis, a known Th1-dominant condition.
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Authors
Isabelle Miyazawa, Toshiaki Abe, Koichi Narikawa, Juan Feng, Tatsuro Misu, Ichiro Nakashima, Juichi Fujimori, Makoto Tamai, Kazuo Fujihara, Yasuto Itoyama,