Ischemic damage and early inflammatory infiltration are different in the core and penumbra lesions of rat brain after transient focal cerebral ischemia

The ischemic lesions in the penumbra are dominated by the invasion of inflammatory cells (activated microglia and blood-derived macrophages, polymorphonuclear neutrophils, and T-lymphocytes). Modulation of this pathway represent a potential therapeutical target to reduce the extent of the irreversible tissue damage.345