Balance entre citocinas pro y antiinflamatorias en estados sépticos

From the start of sepsis symptomatology until the day 28, and when clinical disturbances of SIRS are already gone, the global balance among the pro- inflammatory and anti-inflammatory mo-lecules studied aims at a very important increase of anti-inflammatory molecules. The role of TNF-α and IL-1 ß in sepsis seems to be that of triggering factors, but subsequently both lack of pathogenic role. sTNFR-I, sTNFR-II and IL-1 ar have great prognostic value and their levels are related to the development of MODS and to the failure of every organ system. Higher levels of IL-10 and TFR-ß are also related to mortality, although in late phases. Future therapeutic interventions should take into account the fact that sepsis is a dynamic process.