Detection of antibodies to hepatitis C virus: False-negative results in an automated chemiluminescent microparticle immunoassay (ARCHITECT® Anti-HCV) compared to a microparticle enzyme immunoassay (AxSYM HCV Version 3.0)

Our findings indicate that ARCHITECT® Anti-HCV is less sensitive than AxSYM HCV Version 3.0 in detecting antibodies to c22 and c33c in patients who have cleared their HCV-infection and have naturally declining levels of antibodies.