Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9275962 | Clinical Microbiology and Infection | 2005 | 5 Pages |
Abstract
Gemifloxacin MICs for 12 Haemophilus influenzae strains with different resistance phenotypes were 0.001-0.015 mg/L. Gemifloxacin was bactericidal against all 12 strains after 24 h at 2 Ã MIC. Ciprofloxacin, levofloxacin, gatifloxacin and moxifloxacin had MICs of 0.008-0.03 mg/L and similar kill kinetics. Macrolides and telithromycin had unimodal MICs (1.0-8.0 mg/L), except for two strains without efflux systems (0.0125-0.5 mg/L) and two with efflux systems and ribosomal protein mutations (> 64.0 mg/L), and were bactericidal against eight to ten strains tested at 2 Ã MIC after 24 h.
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Authors
G.A. Pankuch, G. Lin, P.C. Appelbaum,