| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9275988 | Clinical Microbiology and Infection | 2005 | 4 Pages |
Abstract
This study evaluated the clinical and microbiological characteristics of 16 patients who were colonised or infected with 26 isolates of pandrug-resistant Pseudomonas aeruginosa (PDRPA; intermediately-resistant or resistant to all cephalosporins, piperacillin-tazobactam, aztreonam, carbapenems, ciprofloxacin and aminoglycosides) in a university hospital during 1999-2002. All the isolates had colistin MICs â¤4 mg/L, 19 (73%) isolates had blaVIM-3, and 25 (96%) isolates had class I integrons (intI). Time-kill studies for two PDRPA blood isolates demonstrated synergism for cefepime-amikacin after 24 h. Pulsed-field gel electrophoresis analysis of the isolates revealed a polyclonal nature (12 pulsotypes), although clonal dissemination of PDRPA isolates among these patients was also present.
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Authors
P.R. Hsueh, S.P. Tseng, L.J. Teng, S.W. Ho,