Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9276522 | Current Opinion in Microbiology | 2005 | 9 Pages |
Abstract
The mammalian cell cycle is involved in many processes - such as immune responses, maintenance of epithelial barrier functions, and cellular differentiation - that affect the growth and colonization of pathogenic bacteria. Therefore it is not surprising that many bacterial pathogens manipulate the host cell cycle with respect to these functions. Cyclomodulins are a growing family of bacterial toxins and effectors that interfere with the eukaryotic cell cycle. Here, we review some of these cyclomodulins such as cytolethal distending toxins, vacuolating cytotoxin, the polyketide-derived macrolide mycolactone, cycle-inhibiting factor, cytotoxic necrotizing factors, dermonecrotic toxin, Pasteurella multocida toxin and cytotoxin-associated antigen A. We describe and compare their effects on the mammalian cell cycle and their putative role in disease, commensalism and symbiosis. We also discuss a possible link between these cyclomodulins and cancer.
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Authors
Eric Oswald, Jean-Philippe Nougayrède, Frédéric Taieb, Motoyuki Sugai,