Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9276665 | Current Opinion in Microbiology | 2005 | 7 Pages |
Abstract
In many pathogenic bacteria, genes that encode virulence factors are located in the genomes of prophages. Clearly bacteriophages are important vectors for disseminating virulence genes, but, in addition, do phage regulatory circuits contribute to expression of these genes? Phages of the λ family that have genes encoding Shiga toxin are found in certain pathogenic Escherichia coli (known as Shiga toxin producing E. coli) and the filamentous phage CTXÏ, that carries genes encoding cholera toxin (CTX), is found in Vibrio cholerae. Both the λ and CTXÏ phages have repressor systems that maintain their respective prophages in a quiescent state, and in both types of prophages this repressed state is abolished when the host cell SOS response is activated. In the λ type of prophages, only binding of the phage-encoded repressor is involved in repression and this repressor ultimately controls Shiga toxin production and/or release. In the CTXÏ prophage, binding of LexA, the bacterial regulator of SOS, in addition to binding of the repressor is involved in repression; the repressor has only limited control over CTX production and has no influence on its release.
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Authors
Matthew K Waldor, David I Friedman,