| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9277272 | Enfermedades Infecciosas y Microbiología Clínica | 2005 | 7 Pages |
Abstract
Quinolone resistance is caused mainly by chromosomal mutations in gram negative bacteria. In 1998, plasmidmediated resistance to quinolones in clinical isolates was first reported in a Klebsiella pneumoniae strain. Locus qnr (quinolone resistance) was responsible of the quinolone resistance in this plasmid. qnr codes a protein whose function is protect both DNA-girase and topoisomerase IV from these antimicrobials. Moreover, qnr is located in an integron-like structure upstream of qacEÎ1 y sull. A review of the information obtained in the last years about this mechanism of resistance was performed.
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Authors
José Manuel RodrÃguez-MartÃnez,