| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9277289 | Enfermedades Infecciosas y Microbiología Clínica | 2005 | 7 Pages |
Abstract
Transcriptional activation of HIV-1 gene expression is controlled in part by the interaction of viral and cellular transcription factors with the HIV-1 long terminal repeat (LTR) sequences. LTR variability among different HIV-1 subtypes could affect LTR binding of either cellular or viral elements, influencing the transcription level. This effect, in turn, may have consequences on the biology of the different HIV-1 clades and on disease progression. In some circumstances, a relationship between replication capacity in vitro and changes in binding sequences for transcription factors located at the LTR has been proven.
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Authors
Eva RamÃrez de Arellano, Vicente Soriano, África HolguÃn,