Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9341902 | Experimental Eye Research | 2005 | 15 Pages |
Abstract
Retinal degenerations, regardless of the initiating event or gene defect, often result in a loss of photoreceptors. This formal deafferentation of the neural retina eliminates the intrinsic glutamatergic drive of the sensory retina and, perhaps more importantly, removes coordinated Ca++-coupled signaling to the neural retina. As in other central nervous system degenerations, deafferentation activates remodeling. Neuronal remodeling is the common fate of all photoreceptor degenerations.
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Authors
Bryan W. Jones, Robert E. Marc,