Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9528 | Biomaterials | 2009 | 5 Pages |
Abstract
We report the formation of polysiloxane polymers containing embedded methylene blue and gold nanoparticles incorporated by a swell-encapsulation-shrink method. These polymers show significant antimicrobial activity against methicillin-resistant Staphylococcus aureus and Escherichia coli with up to a 3.5 log10 reduction in the viable count when exposed for 5 min to light from a low power 660 nm laser. The bacterial kill is due to the light-induced production of singlet oxygen and other reactive oxygen species by the methylene blue. Interestingly, the presence of 2 nm gold nanoparticles significantly enhanced the ability of the methylene blue to kill bacteria.
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Authors
Stefano Perni, Clara Piccirillo, Jonathan Pratten, Polina Prokopovich, Wojciech Chrzanowski, Ivan P. Parkin, Michael Wilson,