Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9602651 | Enzyme and Microbial Technology | 2005 | 12 Pages |
Abstract
A simple temperature-shift method (28-23 °C) was proved surprisingly valuable to the fermentation process. Such experiments showed that the maximum of lovastatin production was further enhanced by 25% (572 mg/l at day 10) in comparison with that when the fungus was cultured at 28 °C. The timing to initiate the temperature-shift (96 h) corresponded to that of pellet formation and the subsequent core compactness. Hence, it was found that lovastatin production by A. terreus favored sub-optimal growth conditions.
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Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Long-Shan T. Lai, Tai-Her Tsai, Te Chi Wang, Tsung-Yao Cheng,