Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9603197 | Journal of Bioscience and Bioengineering | 2005 | 7 Pages |
Abstract
A new family of NAD(P)H-dependent oxidoreductases is now recognized as a protein family distinct from conventional Rossmann-fold proteins. Numerous putative proteins belonging to the family have been annotated as malate dehydrogenase (MDH) or lactate dehydrogenase (LDH) according to the previous classification as type-2 malate/L-lactate dehydrogenases. However, recent biochemical and genetic studies have revealed that the protein family consists of a wide variety of enzymes with unique catalytic activities other than MDH or LDH activity. Based on their sequence homologies and plausible functions, the family proteins can be grouped into eight clades. This classification would be useful for reliable functional annotation of the new family of NAD(P)H-dependent oxidoreductases.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Hisashi Muramatsu, Hisaaki Mihara, Masaru Goto, Ikuko Miyahara, Ken Hirotsu, Tatsuo Kurihara, Nobuyoshi Esaki,