| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9604379 | Journal of Biotechnology | 2005 | 8 Pages |
Abstract
Bioassay-guided fractionation led to the identification of several fractions enhancing or moderately reducing the enzyme activity. Strong inhibitory effects were detected in the ethyl acetate and the n-butanol fractions of the baked bean ascidian, Dendrodoa grossularia. NMR analysis indicated the presence of the guanidinostyrene derivative tubastrine. This is the first documentation of this metabolite in ascidians. Structure analysis of tubastrine in comparison to other known PTK inhibitors may enhance our understanding of the structure and effect of the compounds and may help in the development of efficient therapeutic agents.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Jana S. Barenbrock, Matthias Köck,