Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9607112 | Journal of Photochemistry and Photobiology B: Biology | 2005 | 7 Pages |
Abstract
The photosensitizing properties of six anthraquinones (AQs): soranjidiol (1), soranjidiol-1-methyl ether (2), rubiadin (3), rubiadin-1-methyl ether (4), damnacanthal (5) and damnacanthol (6), isolated from leaves and stems of Heterophyllaea pustulata Hook. f. (Rubiaceae) were studied. By means of photobiological and photophysical methods in vitro, the type of photosensitization that these metabolites are capable of producing was determined. Whereas the photosensitized generation of superoxide anion radical (O2-) (Type I) was evaluated in leukocyte suspensions, singlet molecular oxygen (1O2) production (Type II) was examined in organic solution. In addition, the quantum yield of 1O2 (Φ) in chloroform was measured for those AQs that generate it. It was established that 4 behaves exclusively as a Type I photosensitizer. By contrast, the others AQs act by both types of mechanisms, among which 5 showed the largest Φ of 1O2.
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Authors
Susana C. Núñez Montoya, Laura R. Comini, MartÃn Sarmiento, Cecilia Becerra, Inés Albesa, Gustavo A. Argüello, José L. Cabrera,