Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9646303 | Schizophrenia Research | 2005 | 8 Pages |
Abstract
The results provide a better framework for understanding the clinical meaning of the PANSS total score in drug trials of schizophrenia patients with acute exacerbations. Such studies may ideally use at least a 50% reduction from baseline cut-off to define response rather than lower thresholds. In treatment resistant populations, however, even a small improvement can be important, so that a 25% cut-off might be appropriate.
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Authors
Stefan Leucht, John M. Kane, Werner Kissling, Johannes Hamann, Eva Etschel, Rolf R. Engel,