Contrasting loxapine to its isomer isoloxapine-the critical role of in vivo D2 blockade in determining atypicality

Loxapine's behaviour as a typical antipsychotic is most likely due to its disproportionately high D2 occupancy. Appropriate action at D2 receptors in vivo, rather than the high 5-HT2 / D2 ratio, seems to be critical in determining why isoloxapine behaves like an atypical antipsychotic.