Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9646481 | Schizophrenia Research | 2005 | 6 Pages |
Abstract
Recently the expression of human myelin/oligodendrocyte glycoprotein (MOG) has been found to be significantly downregulated in the brain tissue of subjects with schizophrenia, suggesting that the MOG gene resides within a high-susceptibility locus for schizophrenia. In order to test this prediction, we analyzed three microsatellites from MOG in the Han Chinese population using a sample of 532 trios. Analysis of allele, genotype and haplotype frequencies showed weak positive association between the markers and the disease (p=0.01982). Our results would indicate that the MOG gene may play a significant role in schizophrenia in the Han Chinese. However, further study is required using other methods and involving other populations.
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Authors
Xinmin Liu, Wei Qin, Guang He, Yifeng Yang, Qi Chen, Jian Zhou, Dawei Li, Niufan Gu, Yifeng Xu, Guoyin Feng, Hong Sang, Xinming Hao, Kui Zhang, Shiji Wang, Lin He,