Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9743428 | Analytica Chimica Acta | 2005 | 5 Pages |
Abstract
Based on the theory of stochastic resonance, a new method carried on the quantitive analysis to weak chromatographic signal of glyburide in plasma, which was embedded in the noise background and the signal-to-noise ratio (SNR) of HPLC-UV is enhanced remarkably. This method enhances the quantification limit to 1 ng mlâ1, which is the same as HPLC-MS, and makes it possible to detect the weak signal accurately by HPLC-UV, which was not suitable before. The results showed good recovery and linear range from 1 to 50 ng mlâ1 of glyburide in plasma and the method can be used for quantitative analysis of glyburide.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Wei Zhang, Bingren Xiang, Yanwei Wu, Erxin Shang,