Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9743879 | Analytica Chimica Acta | 2005 | 6 Pages |
Abstract
A new method to determine paracetamol and p-aminophenol in pharmaceutical products is presented. The purpose of this work is to introduce 2,2â²-(1,4-phenylenedivinylene) bis-8-hydroxyquinoline (PBHQ) as a novel coupling agent. This developed method is based on the microwave assisted alkaline hydrolysis of paracetamol to p-aminophenol, which reacts in mildly alkaline medium with 2,2-(1,4-phenylenedivinylene)bis-8-hydroxyquinoline (PBHQ) as a novel coupling reagent. The formed product shows maximum absorbance at 650 nm with molar absorptivity = 3.4 Ã 104 l molâ1 cmâ1 and the method was linear in the 0.44-5.5 mg lâ1 concentration range. The detection limit value was found to be 0.09 μg mlâ1. The stoichiometric composition of the dye is 2:1 (PAP:PBHQ). The effect of concentration of reactants and temperature on the coupling reaction was investigated. The proposed method is successfully adopted for the determination of paracetamol and p-aminophenol in various pharmaceutical preparations.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Hayati Filik, Mustafa Hayvali, Emine Kilic,