Determination of alkylphenol and bisphenol A in beverages using liquid chromatography/electrospray ionization tandem mass spectrometry

A comprehensive analytical method based on liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) with negative ionization mode has been developed for measuring of alkylphenols and bisphenol A in beverage samples. Concentration and clean up of samples were performed on 200 mg OASIS HLB solid extraction cartridges. The effects of mobile phases and additives on ionization were assessed. The recoveries for each compound ranged from 76.7 to 96.9% and reproducibilities were represented as having relative standard deviation (R.S.D.) below 10%. The limits of quantification (LOQ) of the method under multiple-reaction monitoring (MRM) acquisition mode were 0.04, 0.03 and 0.2 ng L−1 for 2 L of mineral drinking water and 2.0, 1.8 and 8.0 ng L−1 for 50 mL of soda beverages.