Metabolism and depletion of nifursol in broilers

Concentrations of non-extractable residue at zero withdrawal time averaged to 900 μg/kg in liver tissue, 2000 μg/kg in kidney tissue, 225 μg/kg in muscle tissue, 1000 μg/kg in bile and 1000 μg/kg in plasma. Taking into account an LoD of 1 μg/kg, non-extractable residues of DNSH can be detected for at least 3 weeks after administration in liver, kidney, bile and plasma and for up to 2 weeks in muscle tissue. The amounts of extractable residues were relatively low, in many instances less than 10% of the total amount of residue. In general terms the depletion data obtained show a similar behaviour of nifursol in broilers as previously found for furazolidone and furaltadone in broilers.