| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9769989 | Journal of Molecular Structure | 2005 | 6 Pages |
Abstract
Photoirradiation of O-hydroxylcyclohexyletheramine-doxorubicin (dox) when bound to DNA exhibits high DNA cleavage efficiency and selectivity, leading to GG steps cleavage. Coupling ultraviolet absorption with viscosity measurement, the mode of dox-DNA complex is groove-binding. The three-dimensional structure from X-ray crystallography reveals that dox bound to DNA base pairs to groove reversal along with its antenna (hydroxylcyclohexylether-amine) in the major groove. We also provide a direct evidence of supporting a model that transfers electrons from base to dox and holes migrate within DNA.
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Authors
Long B. Liao, Hai Y. Zhou, Xian M. Xiao,