| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9876372 | Radiation Physics and Chemistry | 2005 | 8 Pages |
Abstract
Irradiation of the free lac repressor with γ-rays abolishes protein's ability to specifically bind operator DNA. A possible radiation-induced protein damage is a dityrosine (DTyr) formed by two spatially close radiation-induced tyrosyl radicals. We performed the molecular modeling of complexes between operator DNA and DTyr-bearing parts (headpieces) of the repressor. The presence of DTyr affects the structure and the interactions between partners. A detailed analysis allows to conclude this damage can partially account for the loss of repressor ability to bind DNA.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Julien Gras, Denise Sy, Séverine Eon, Michel Charlier, Melanie Spotheim-Maurizot,