Article ID Journal Published Year Pages File Type
9885512 Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 2005 5 Pages PDF
Abstract
CCL15 exerts biological effects on a variety of cells, including monocytes. NF-κB has been reported to be involved in the transcription of the CCL15 gene. In this study, we have identified an AP-1 element located at −76/−65, which appears to regulate the transcription of the CCL15 gene. We also confirmed that the AP-1 factor binds to the element. Specific inhibitors for MAPK pathways and expression of dominant negative MKK4 or JNK1 reduced PMA-induced transcriptional activation of CCL15. Our findings indicate that transcription of the CCL15 gene is regulated by AP-1 and NF-κB through MEK and JNK MAPK pathways in monocytoid cells.
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