Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9885512 | Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | 2005 | 5 Pages |
Abstract
CCL15 exerts biological effects on a variety of cells, including monocytes. NF-κB has been reported to be involved in the transcription of the CCL15 gene. In this study, we have identified an AP-1 element located at â76/â65, which appears to regulate the transcription of the CCL15 gene. We also confirmed that the AP-1 factor binds to the element. Specific inhibitors for MAPK pathways and expression of dominant negative MKK4 or JNK1 reduced PMA-induced transcriptional activation of CCL15. Our findings indicate that transcription of the CCL15 gene is regulated by AP-1 and NF-κB through MEK and JNK MAPK pathways in monocytoid cells.
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Authors
Yong-Hyun Shin, Kyung-No Son, Guy Wilhem Lee, Byoung S. Kwon, Jiyoung Kim,