Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9885603 | Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | 2005 | 7 Pages |
Abstract
The microtubule-associated protein (MAP) tau is found primarily in neurons and errors in its regulation are associated with Alzheimer's disease and other neurodegenerative disorders. Tau expression is transcriptionally regulated and tissue-specific. In this study, starting with a â¼7500-bp fragment from the mouse tau gene, which includes tau exon â1, we define regions preferentially conferring tissue-specific expression. Furthermore, gel shift assays indicate that transcriptional regulators SP-1 and AP-2 are important for basal expression but not necessary for neuron-specific expression of the tau transcript.
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Authors
Lei Gao, Kerry L. Tucker, Athena Andreadis,