Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9886114 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2005 | 11 Pages |
Abstract
PSP/Lithostathine/PTP/regI, PAP/p23/HIP, reg1L, regIV and “similar to PAP” are the members of a multifunctional family of secreted proteins containing a C-type lectin-like domain linked to a short N-terminal peptide. The expression of this group of proteins is controlled by complex mechanisms, some members being constitutively expressed in certain tissues while, in others, they require activation by several factors. These members have several apparently unrelated biological effects, depending on the member studied and the target cell. These proteins may act as mitogenic, antiapoptotic or anti-inflammatory factors, can regulate cellular adhesion, promote bacterial aggregation, inhibit CaCO3 crystal growth or increase resistance to antitumoral agents. The presence of specific receptors for these proteins is suggested because biological effects were observed after the addition of purified protein to culture media or after systemic administration to animals, whereas other biological effects could be explained by their biochemical capacity to form homo or heteromers or to form insoluble fibrils at physiological pH.
Keywords
IL1HMG-I/YPI3-kinaseCTLDIL22MEK1TNBSIL10IFNγIL6PAPADPpKaPTPSTAT3TNFαLPSCNTFRT-PCRGRFPSPMPONFκBStat1adenosine diphosphateTrinitrobenzene sulfonic acidinterleukin 1Interleukin 10Interleukin 22interleukin 6tumor necrosis factor alphaGrowth hormone-releasing factorciliary neurotrophic factornuclear factor kappa Bphosphoinositide-3-kinaseC-type lectinlipopolysaccharidesignal transducer and activator of transcription 1signal transducer and activator of transcription 3HIPmyeloperoxidaseReverse transcriptase-polymerase chain reactionpancreatic stone proteinpancreatitis-associated proteinprotein kinase AInterferon gamma
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Authors
Juan L. Iovanna, Jean-Charles Dagorn,