Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9886598 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2005 | 8 Pages |
Abstract
Insulin resistance-related obesity and diabetes mellitus are the predominant causes of fatty liver disease. Here we examine the effects of dietary diacylglycerol (DG), which is a minor component of plant oils, on lipid accumulation and the expression of genes involved in lipid metabolism in the liver. The animals were fed diets containing either 10% triacylglycerol (TG), 10% TG+4% α-linolenic acid-rich TG (ALATG) or 10% TG+4% α-linolenic acid-rich diacylglycerol (ALADG) for a period of 1 month. Supplementation with ALADG significantly inhibited hepatic triglyceride accumulation; this was accompanied by the up-regulation of β-oxidation activity, and acyl-CoA oxidase (ACO) and medium-chain acyl-CoA dehydrogenase (MCAD) mRNA levels. By contrast, no significant changes were observed in the levels of peroxisome proliferator-activated receptor-α (PPARα) and sterol regulatory element-binding protein-1 (SREBP-1) mRNAs. These results indicate that ALADG might be useful in the prevention of fatty liver formation; this effect could be closely related to the stimulation of lipid catabolism in the liver. In addition, our findings suggest that both acylglycerol structure (that is, the structural difference between TG and DG) and fatty-acid species affect the nutritional behaviour of dietary lipids.
Keywords
EPASREBPNAFLDMCADDGATPPARRT-PCRACOACATALANIDDMacyl-CoA oxidaseβ-oxidationNon-alcoholic steatohepatitisα-linolenic acidEicosapentaenoic aciddocosahexaenoic acidnon-esterified fatty acidsNEFAsWhite adipose tissuesGOTnon-alcoholic fatty liver diseasetriacylglycerolDHAnon-insulin-dependent diabetes mellitusdiacylglycerolDiacylglycerol acyltransferaseMedium-chain acyl-CoA dehydrogenaseObesityNash reverse transcription-polymerase chain reactionSterol regulatory element-binding proteinFatty liverglutamate oxaloacetate transaminaseperoxisome proliferator-activated receptor
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Authors
Takatoshi Murase, Masafumi Aoki, Ichiro Tokimitsu,