Article ID Journal Published Year Pages File Type
9887796 Biochimie 2005 9 Pages PDF
Abstract
HIV-1 RNase H and integrase both belong to the phosphotransferase family and share structural similarities. An interesting result was obtained when the DNA aptamers initially raised against p15 RNase H were assayed against HIV-1 integrase. In contrast to RNase H, the HIV-1 integrase was inhibited by these aptamers. Our results point out that prototype structures can be exploited to develop inhibitors of two related enzymes.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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