Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9887796 | Biochimie | 2005 | 9 Pages |
Abstract
HIV-1 RNase H and integrase both belong to the phosphotransferase family and share structural similarities. An interesting result was obtained when the DNA aptamers initially raised against p15 RNase H were assayed against HIV-1 integrase. In contrast to RNase H, the HIV-1 integrase was inhibited by these aptamers. Our results point out that prototype structures can be exploited to develop inhibitors of two related enzymes.
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Authors
Mathieu Métifiot, Oscar Leon, Laura Tarrago-Litvak, Simon Litvak, Marie-Line Andréola,