Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9887971 | Clinica Chimica Acta | 2005 | 23 Pages |
Abstract
Serum lipase is a more reliable diagnostic marker of AP than serum amylase. Urinary strip tests for trypsinogen activation peptide (TAP) and trypsinogen-2 provide a reliable early diagnosis of AP. Useful predictors of severity may include serum procalcitonin and urinary TAP and trypsinogen-2 on admission, serum interleukins-6 and -8 and polymorphonuclear elastase at 24 h, and serum C-reactive protein (CRP) at 48 h. Other markers such as amyloid A and carboxypeptidase B activation peptide (CAPAP) need further investigation. Biochemical prediction of pancreatic necrosis requires 72 h to reach reliability and is impractical. However, the daily monitoring of serum procalcitonin provides a non-invasive detection of infected necrosis; the promising role of phospholipase A2 in this regard requires further investigation. Early transient hypertransaminasemia reliably predicts biliary etiology, while serum carbohydrate-deficient transferrin and trypsin may predict an alcoholic etiology.
Keywords
PMNEUSPLRALTNLRHCTPPVSTMICAM-1PLA2ANPMCVAPACHECDTsICAM-1TNFUSSU/LNPVERCPEndoscopic retrograde cholangiopancreatographyASTalanine transaminaseALPAlkaline phosphatasehuman leucocyte antigenHLAphospholipase A2positive predictive valuenegative predictive valueMRICarbohydrate-deficient transferrininterleukinsaspartate transaminasesoluble thrombomodulinDiagnosisMagnetic resonance imagingcomputerized tomographyMean corpuscular volumeendoscopic ultrasoundSeveritySAPTAPGranulocyte colony stimulating factortumour necrosis factorNumberInfectionG-CSFUltrasoundAcute Physiology and Chronic Health Evaluationlactate dehydrogenaseLDHintercellular adhesion molecule-1soluble intercellular adhesion moleculepositive likelihood rationegative likelihood ratioMarkersURLPancreatic necrosishaematocritinternational unitAcute pancreatitisSevere acute pancreatitisAcute necrotizing pancreatitisC-reactive proteinCRPPolymorphonuclearTrypsinogen activation peptide
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Authors
Ahmed Z. Al-Bahrani, Basil J. Ammori,