| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9888005 | Clinica Chimica Acta | 2005 | 9 Pages |
Abstract
The results did not show a distinct preference of 5â²NT activity for any of the tested thiopurine nucleotides. The enzyme kinetic studies furthermore revealed substrate inhibition by thio-IMP and thio-GMP as a substrate. Inhibition by thio-GMP also seems to occur in patients treated with 6-mercaptopurine (6 MP); subsequently, this may lead to toxicity in these patients.
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Authors
Connie Brouwer, Trude M. Vogels-Mentink, Jenneke J. Keizer-Garritsen, Frans J.M. Trijbels, Jos P.M. Bökkerink, Peter M. Hoogerbrugge, Elisabeth R. van Wering, Anjo J.P. Veerman, Ronney A. De Abreu,