Relationship between plasma HDL subclasses distribution and apoA-I gene polymorphisms

The G/A polymorphism at − 78 bp of apoA-I gene was associated with changes of HDL subclasses distribution. There was a general shift towards smaller-sized HDL, which, in turn, indicated that reverse cholesterol transport (RCT) might be weakened and HDL maturation might be abnormal in the subjects with G/A mutation.