A beneficial effect of simvastatin on DNA damage in 242T allele of the NADPH oxidase p22phox in hypercholesterolemic patients

Article ID	Journal	Published Year	Pages	File Type
9888029	Clinica Chimica Acta	2005	6 Pages	PDF

Abstract

Simvastatin significantly reduced DNA damage of hypercholesterolemic patients. This study showed that simvastatin has a beneficial effect on the improvement of DNA damage in patients with the 242T allele of NADPH oxidase p22phox gene.

Keywords

NADPH IMT ROS DNA damage NADPH oxidase Cerebrovascular disease coronary artery disease CVD Simvastatin body mass index BMI Intima-media thickness CAD nicotinamide adenine dinucleotide phosphate Polymorphism Reactive oxygen species

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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A beneficial effect of simvastatin on DNA damage in 242T allele of the NADPH oxidase p22phox in hypercholesterolemic patients

Authors

Min-Jeong Shin, Eun Young Cho, Yangsoo Jang, Jong Ho Lee, Won-Heum Shim, Seung-Yun Cho, Se-Joong Rim, Seok-Min Kang, Jong-Won Ha, Young-Guk Ko, Sung-Soon Kim, Hyun Young Park, Namsik Chung,