Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9888032 | Clinica Chimica Acta | 2005 | 14 Pages |
Abstract
A progressive decline in the enzyme activities involved in tryptophan metabolism along the kynurenine pathway in rat tissues was found with age, except for aminocarboxymuconate-semialdehyde decarboxylase, which, on the contrary, was increased after 2-3 months to the other older groups of age. The altered metabolism of tryptophan with ageing can lead to a decreased biosynthesis of nicotinic acid, tryptophan being the major source of body stores of NAD coenzymes, which are involved in almost all biogenetic and biosynthetic pathways of the organism.
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Authors
Stefano Comai, Carlo V.L. Costa, Eugenio Ragazzi, Antonella Bertazzo, Graziella Allegri,