Western blot analysis of human and rat serotonin transporter in platelets and brain using site-specific antibodies: Evidence that transporter undergoes endoproteolytic cleavage

The explanation of the results of immunoblotting most likely is a site-specific SERT endoproteolytic cleavage and a marked difference in glycosylation rather than nonspecific protein degradation, cross-reactivity with other epitopes or SERT alternative splicing.