Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9889951 | The International Journal of Biochemistry & Cell Biology | 2005 | 13 Pages |
Abstract
Cytokines play an essential role in mediating interactions between cells of the immune system. Suppressors of cytokine signalling proteins act to negatively regulate these cytokine signals, thereby exerting control over the expression of cytokine responsive genes. Various lines of experimental evidence suggest that two closely related members of the this family, suppressor of cytokine signalling 1 and 3, are important in the processes of T cell development, activation and homeostasis. This review outlines the principles underlying these processes and relates these to the potentially important roles played by suppressor of cytokine signalling 1 and 3.
Keywords
CISGSTSOCS proteinsTCrRAG-2SH2APCPAMPSHP-1SOCSSCFJanus kinaseSrc-homology 2STATinterferonIFNinterleukinsingle positiveThymopoiesisdouble positivesuppressor of cytokine signallingantigen presenting cellTriple negativeStem Cell FactorT cell activationsignal transducers and activators of transcriptionmajor histocompatibility complexMHCImmune regulationpathogen associated molecular patternsJAKglutathione S-transferaseT cell receptor
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Authors
Joel Fletcher, Robyn Starr,