Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9889967 | The International Journal of Biochemistry & Cell Biology | 2005 | 6 Pages |
Abstract
The commonly used diureticum furosemide targets one of the transporters present in these tubular cells with resulting diuresis. Several pathological states are associated with altered function of the medullary tubular cells, and the nephrotoxic substances tacrolimus and cyclosporine act on these cells. The specific Tamm-Horsfall glycoprotein is produced by medullary tubular cells. Alteration in the urinary excretion of this protein is used as marker of tubular damage.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Fredrik Palm, Per-Ola Carlsson,