Article ID Journal Published Year Pages File Type
9890052 The International Journal of Biochemistry & Cell Biology 2005 20 Pages PDF
Abstract
The active site of the enzyme contains, in addition to FAD, three amino acid side chains that are intimately involved in catalysis: His516 with a pKa = 6.9, and Glu412 with pKa = 3.4 which is hydrogen bonded to His559, with pKa > 8. The protonation of each of these residues has a strong influence on all rate constants in the catalytic mechanism.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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