Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9893555 | Pharmacology Biochemistry and Behavior | 2005 | 12 Pages |
Abstract
Two weeks after exposure, PB+sarin caused significant rCBF elevations, but no changes in rCGU, in neocortex, with lesser effects on allocortex. Four weeks after exposure, the same general pattern was found with sarin. Only a few changes were found at 16 weeks post-treatment. The predominant effects of sarin or PB+sarin on rCBF at earlier times after treatment are consistent with the well known direct cerebral vascular effect of cholinergic agonists. The lack of changes in rCBF and rCGU observed at 16 weeks after treatment does not support the hypothesis that repeat exposure to low-dose cholinesterase inhibitors can generate permanent alterations in cerebral activity.
Keywords
primary motorRegional cerebral glucose utilizationRetrosplenialdeoxyglucoseEntorhinalPiriformrCBFprimary somatosensoryECTAu1IAPbutyrylcholinesteraseBuChERBCENTRed blood cellsAmygdalaAChEOrganophosphoruscerebral glucose utilizationAcetylcholinesterasePirRegional cerebral blood flowInsularSarinAuditoryNerve agentsTemporalBarrel fieldPyridostigmine bromideChATcholineacetyltransferaseCerebrovascular circulation
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Authors
Oscar U. Scremin, Tsung-Ming Shih, Ly Huynh, Margareth Roch, Wei Sun, Dante R. Chialvo, Donald J. Jenden,