Article ID Journal Published Year Pages File Type
9894069 Prostaglandins & Other Lipid Mediators 2005 9 Pages PDF
Abstract
It is postulated that lipophilic ligands reach their sites of action on membrane-bound functional proteins through fast lateral diffusion across the membrane bilayer. We have shown using NMR experiments that such ligands when incorporated in a membrane system assume a preferred orientation and conformation. While occupying a specific location within the bilayer, these molecules undergo fast lateral diffusion which allows them to engage in productive interactions with their respective protein sites of action. The proposed model is discussed using a group of classical and non-classical cannabinoids as well as the endogenous cannabinoid ligand anandamide.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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