Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9894351 | Regulatory Peptides | 2005 | 8 Pages |
Abstract
Our results indicate that pathophysiological increases in plasma leptin concentrations cause enhanced renal Na, Cr and protein excretions, and high circulating ET-1 levels. Na and Cr excretions were decreased, while proteinuria and plasma ET-1 levels were normalized by losartan treatment, suggesting that renin-angiotensin system activation may have a role in leptin induced renal changes. TGF-β1 may have an important role in leptin induced nephropathy.
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Authors
Zubeyde Gunduz, Nurcan Dursun, Hulya Akgun, Figen Ozturk, Hamit Okur, Nedret Koc,