| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9894395 | Regulatory Peptides | 2005 | 10 Pages |
Abstract
The present observations on isolated ECL cells suggest that Ca2+ entry rather than mobilization of internal Ca2+ triggers exocytosis, that gastrin and PACAP activate different (but over-lapping) Ca2+ channels, that somatostatin, misoprostol and galanin interact with inhibitory G-proteins to block Ca2+ entry via L-type Ca2+ channels, and that somatostatin and misoprostol (but not galanin) in addition block N-type and/or receptor-operated Ca2+ channels.
Keywords
PRLethylenedinitrilo tetraacetic acid(Ca2+)iReceptor-operated Ca2+ channelVPACPAC1somatostatin receptor type 2CCK2RPTXEP3PACAPDMEMPGE2HEPESROCVIP4-(2-hydroxyethyl)-1-piperazineethane-sulfonic acidBSAcAMPDulbecco's modified Eagle's mediumCyclic adenosine monophosphatebovine serum albuminEDTAGDPBay K 8644pertussis toxinSomatostatinintracellular Ca2+ concentrationMisoprostolProstaglandin E2vasoactive intestinal peptidepituitary adenylate cyclase-activating peptidegastrinGalaninguanosine diphosphate
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Authors
Maria Björkqvist, Maria Bernsand, Lena Eliasson, Rolf HÃ¥kanson, Erik Lindström,